Discerna

DAPA schematic

Discerna was established from technology developed at the Babraham Institute in 2001 on the expertise of its founders in immunology and protein engineering.

Recognising the commercial potential of recombinant protein-based products, particularly antibodies, the Company has created a platform of technologies that both improve upon and complement established methods of developing biopharmaceuticals. (Publications)

 

The Discerna Company has out-licensed two technologies in a number of geographical
and technical areas:

ribosome display
  1. Ribosome Display technology
  2. Protein Printing array technology.

The use of ribosome display technology in therapeutics has been assigned to:
Crescendo Biologics
www.crescendobiologics.com

Partners for the licensing of the ribosome display technology outside the therapeutics field are still actively sought.

 

 

Contact:

c/o Babraham Bioscience Technologies Ltd.
info@discerna.co.uk

+44 (0)1223 496269

 

Patent Families

Ribosome Display Technology
Ribosome Complexes as Selection Particles For In Vitro Display And Evolution Of Proteins (link)
Priority Date: 28th May 1997

Granted in: Australia, Europe, US
Pending in: Canada, Japan

 

Protein Array Technology
Functional Protein Arrays (link)
Priority Date: 15th August 2000

Granted in: Australia, Canada, Europe, Japan, US

 

Publications

Ribosome Display Technology

He M and Taussig MJ (2007)
Eukaryotic Ribosome Display with in situ DNA Recovery.
Nature Methods 4: 281-288 (link)

He M and Taussig MJ (2005)
Ribosome display of antibodies: expression, specificity and recovery in a eukaryotic system.
J Immunol Methods 297:73-82 (link)

He M and Taussig MJ (2002)
Ribosome display: cell-free protein display technology.
Brief Funct Genomic Proteomic 1:204-12 (link)

He M, Cooley N, Jackson A, Taussig MJ (2004)
Production of human single-chain antibodies by ribosome display.
Methods Mol Biol 248:177-89 (link)

He M, Menges M, Groves MA, Corps E, Liu H, Bruggemann M, Taussig MJ (1999)
Selection of a human anti-progesterone antibody fragment from a transgenic mouse library by ARM ribosome display.
J Immunol Methods 231:105-17 (link)

He M and Taussig MJ (1997)
Antibody-ribosome-mRNA (ARM) complexes as efficient selection particles for in vitro display and evolution of antibody combining sites.
Nucleic Acids Res 25:5132-4 (link)

Protein Array Technology

Stoevesandt O, Vetter M, Kastelic D, Palmer EA, He M, Taussig MJ. Cell free
expression put on the spot: advances in repeatable protein arraying from DNA
(DAPA). N Biotechnol. 2011. 28:282-90 (link)

He M, Stoevesandt O, Palmer EA, Khan F, Ericsson O, Taussig MJ. Printing
protein arrays from DNA arrays. Nat Methods. 2008 5:175-7 (link)

He M and Taussig MJ (2003)
DiscernArray technology: a cell-free method for the generation of protein arrays from PCR DNA.
Immunol Methods 274:265-70 (link)

He M and Taussig MJ (2001)
Single step generation of protein arrays from DNA by cell-free expression and in situ immobilisation (PISA method).
Nucleic Acids Res 29:E73-3 (link)